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Biologist Dr. Cliff Han Presents the Theory behind AllerPops at Cold Spring Harbor Asia Conference: Frontiers of Immunology in Health & Disease

SUZHOU, ChinaSept. 18, 2018 /PRNewswire/ — Creator and founder of the all-natural AllerPops allergy remedy (https://knozejr.com/) recently presented his theories related to allergies and their genesis to an expert international audience. Dr. Han’s research is based on a single yet profound premise: allergies are reversible. Using prebiotics to promote probiotic solutions, Han offers a new and simple way to tackle the worldwide problem of seasonal allergies.

Based on the research performed to find relief for both he and his son’s allergies, Dr. Han unlocked an unexpected secret to the formation of allergies. The discovery led Han to the formation of a prebiotic compound as a way to apply his Theory of Negative Trigger (TNT) to help people take control of their allergies in completely unique way.

TNT expounds on prebiotic stimulation of probiotic interaction in a variety of bacteria naturally present within the oral cavity, specifically: streptococcus and veillonella. Research shows that veillonella and streptococcus are mutualists which produce short chain fatty acids (SCFA). These SCFAs pacify the immune system. Since allergies are related to the unchecked action of the immune system in response to allergens, increased SCFAs should reduce allergic response to allergens and in turn lead to the elimination of unpleasant allergy symptoms.

Dr. Han’s research clearly indicates exactly that. Overall, subjects with increased levels of veillonella present within saliva samples were found to have marked lower instances of allergic response to seasonal allergens. Using Dr. Han’s prebiotic formula, oral probiotics were then specifically increased in subjects with allergies. Those subjects subsequently reported that their allergies were far less severe and, in some cases, eliminated altogether. There is a direct correlation between the level of specific probiotics present within subjects and a decrease in seasonal allergic responses.

TNT describes a general relationship between microbiota and the human immune system. The mechanism is likely evolved for human body to survival peacefully in the world full of bacteria when there is no danger by keeping immune system in control and to have a protective fight at time of invasion of pathogens by releasing the power of immune system promptly. Applying TNT to everyday life, Dr. Han also asserts that:

  • Maintaining low-level fevers is more beneficial than eliminating them.
  • Infants and children should receive their seed microbiota from parents and siblings, not pets or general environments.
  • Periodic fasting to boost the immune system might be beneficial (similar to the benefits received from a sauna).
  • Correct hygiene practices and a good diet can help maintain the proper level of probiotics from the inside out: intestinal tract, respiratory tract and skin.
  • Probiotics should always be reseeded and promoted after severe interruptions in the microbiota (from antibiotic use, illness, etc.).
  • The microbiota switch attached to the power of the immune system may be manipulated readily at will, possibly having other clinical applications such as other allergies, autoimmune diseases, inflammations and perhaps cancer treatment.

About Knoze Jr. and AllerPops

AllerPops from Knoze Jr. is a product developed by Cliff Han. A trained physician in China, Han later worked in the Los Alamos National Laboratory for two decades as a biologist. Suffering from personal, debilitating allergies, Han decided to craft the perfect natural solution: an easy-to-eat lollipop that contains a mixture of prebiotics which encourage healthy flora growth in the body. Using the same logic that fuels the current probiotics food trend of yogurts and smoothies, Han’s patented allergy candy facilitates the growth of the body’s own natural flora; thus encouraging the delicate balance of microorganisms which can help ameliorate allergic reactions. Learn more about Knoze Jr. and AllerPops at Knozejr.com.

Legal Disclaimer

Any inflammation relief obtained by using the product lollipop is supported only by theory and personal observations by the lollipop inventor (e.g. US Pat No._9,795,579) and may not be a typical response. Any representations made herein do not constitute medical advice, and it is recommended that a qualified medical person is consulted before use of the product lollipop. Parental supervision for persons less than 18 years is required according to included instructions.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Contact:

Cliff Han Ph.D., Owner & Founder
Phone: 505 695 4236
Email: 200710@email4pr.com

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AllerPops Announces Amazon Gift Card/People Pay Prizes for Users: Allergy-Suffers Can Share Their Experiences via #iTuneMyAllergiesUsingAllerPops and #Allergies

AllerPops Offers Thank-You Gifts in Appreciation

LOS ALAMOS, N.M., July 18, 2018 /PRNewswire/ — Cliff Han, the maker and founder of AllerPops recently announced a call to gather feedback from customers of his unique allergy-fighting prebiotic lollipops (https://knozejr.com/share-your-experience/). In an effort to connect new customers with the user experiences of past customers, AllerPops initiated #iTuneMyAllergiesUsingAllerPops. Customers are invited to use the hashtag to create and post text messages and video selfies using AllerPops, all while receiving an Amazon gift card or a People Pay award of five dollars as a thank-you gift for each such valid post.

Knoze Jr present AllerPops to the local community at ScienceFest of Los Alamos, NM. Na Leng, and Brian Han help prepare the booth for the quiz on "how to raise an allergy-free child.
Knoze Jr present AllerPops to the local community at ScienceFest of Los Alamos, NM. Na Leng, and Brian Han help prepare the booth for the quiz on “how to raise an allergy-free child.

To participate in the Knoze Jr.’s “Share Your Experience” user feedback forum, users may do one or all of the following:

Post a 30 second selfie video before using AllerPops, documenting the history and symptoms of their allergies.
Post a five second video of themselves eating an AllerPop lollipop.
Post a 20 second selfie video after the last cycle of using the AllerPop lollipops, documenting the overall results.
Merge the footage of pre and post-lollipop use, releasing that footage on Facebook, Twitter or Instagram, while also stamping the footage with the #iTuneMyAllergiesUsingAllerPops and #allergies hashtags.
Regardless of the way users choose to communicate their experiences, to qualify to receive a thank-you award for participation, users must keep in mind that:

All previous and current customers with a proof-of-purchase of AllerPops are eligible. Each valid proof is good for one award.
Each selfie-video or text-entry post must contain the #iTuneMyAllergiesUsingAllerPops and #allergies hashtags.
The post must be consistent with the theme of the AllerPops program, regardless of whether the comments are positive or not.
To redeem the thank-you award, customers can simply email customerservice@knozejr.com with the following info:

A proof-of-purchase of the AllerPops product, such as an Amazon order ID or a photo of the receipt.
Provide a link to the relevant online post made by the user.
Choose a preferred way to receive the award: either an Amazon Gift Card or a People Pay payment. Please also provide an email address associated with an Amazon account or a cell phone number for the People Pay transfer.
About Knoze Jr. and AllerPops

AllerPops from Knoze Jr. is a product developed by Cliff Han. A trained physician in China, Han later worked in the Los Alamos National Laboratory for two decades as a biologist. Suffering from personal, debilitating allergies, Han decided to craft the perfect natural solution: an easy-to-eat lollipop that contains a mixture of prebiotics which encourage healthy flora growth in the body. Using the same logic that fuels the current probiotics food trend of yogurts and smoothies, Han’s patented allergy candy facilitates the growth of the body’s own natural flora; thus encouraging the delicate balance of microorganisms which can help ameliorate allergic reactions. Learn more about Knoze Jr. and AllerPops at Knozejr.com.

Legal Disclaimer

Any inflammation relief obtained by using the product lollipop is supported only by theory and personal observations by the lollipop inventor (e.g. US Pat No._9,795,579) and may not be a typical response. Any representations made herein do not constitute medical advice, and it is recommended that a qualified medical person is consulted before use of the product lollipop. Parental supervision for persons less than 18 years is required according to included instructions.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Contact:

Cliff Han, Owner & Founder

Phone: 505 695 4236

Email: 198471@email4pr.com

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How to Raise an Allergy-free Child

How to Raise an Allergy-free Child

Mission: Seed the child’s microbial communities with ones from mother, father, and sibling, NOT with ones from dog or cat or environment…

 

1. Give birth naturally.

2. Confine baby for at least for a month, for minimal a week with mother together. (Traditionally in China, a baby is confined for the first100 days and together the mother for the first month)

3. Breastfeeding.

4. Sleep with the baby in the same bed.

5. Not bath in first week (gentle wipe openings with wet cloth should be sufficient). Not bath too frequently afterwards. Sweating is not a reason for a bath. Sweat produces conditions, such as high salt concentration, that promote and sustain skin probiotics.

6. Mouth feeding to add foods from 2-3 months (with these sequences: water, soup, semisolid and then solid; starch-rich food, nuts, protein-rich and then veggies). Adult-chewed food is easy for baby to digest, prevent infection, help establish oral and gut microbiota, likely prevent allergies. The caregiver should have no acute infection when doing mouth feeding.

7. Eat AllerPops Prebiotic Lollipops AFTER taking antibiotics, and the targeted disease is cured.

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User’s Manual Got a Makeup

The new version of User’s Manual has been improved for simplicity and effectiveness. It is easier to follow and likely faster in getting allergy relief. It was modified according to customer’s feedbacks.

Anyone who buy Knoze Jr. Prebiotic Lollipop should download the new User’s Manual at https://knozejr.com/users-manual/ and follow the instructions to use.

We encourage everyone who contacted us about our product and service. Your feedback can only make it better. Thank you!

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Sale at Amazon Begins

Our product is now for sale on Amazon on February 11, 2018, with a 50% discount for the first month until March 10, 2018 with satisfaction guaranteed! We encourage all customers to contact us through our website at knozejr.com/contact. Below you’ll find the answers to several frequently asked questions.

 

  1. What are the most important things to remember when using this product?

 

Remember to hold the lollipop in your mouth as long as possible when eating it in order to clear the oral micro-ecospace, and do not chew or swallow it whole.

 

  1. Are there any side effects?

 

We have not observed any side effects. All ingredients found in our product are natural, such as natural sugars, salt, fibers, and amino acids.

 

  1. Will use of this product cause tooth caries?

 

The lollipop, if taken in concurrence with our instruction manual, is intended to promote probiotic growth. These bacteria have one special function, which is to convert lactic acid to less acidic short chain fatty acid. It is likely that the use of this product will, in fact, reduce tooth decay, although this is not its intent and it should not be taken with this goal in mind. Talk with your dentist if you have any special oral conditions.

 

  1. What if, for whatever reason, I am unable to gargle or rinse my mouth out with water?

 

An alternate method is wiping the tongue and other oral surfaces with a washcloth dampened with water of 115 – 120 degrees Fahrenheit for up to 10 minutes. Frequently rewet the cloth to keep it warm.

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Sale start soon

A batch of 200 packages have been sent to Amazon warehouse and received last week. They are being prepared for sell. That could take up to two week. So Knoze Jr Prebiotic Lollipops should be available at Amason by Feb. 22.

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The Four (In)Evitable Things That Are Necessary for Your Health

I want to start with a quick joke. Two friends are in a restaurant. The waiter asks, “Can I take your drink order?” One man says, “I’ll just have some H2O.” His friend says, “I’ll have some H2O too.” The waiter brings the drinks. The first man enjoys a nice glass of water, but the second man dies. This comic illustrates the importance of seeking medical advice from your doctor before making changes to your life. Because sometimes what is said is not the same as what is heard.

With that, I would now like to talk about health in a systematic structure (table below). These are the four major areas of interest: metabolism, immunity, circulation, and mentality. Historically, four things, hunger, germ, hard labor and purpose, have each been closely associated with one of the four systems. On the other ends of inevitable things are the “ideal” conditions man has been striving for, fullness, clean, rest, and freedom. The four inevitable things have been associated with human life since the beginning of our species. They are considered inevitable because they can’t be avoided due to limited food, knowledge, and technology. However, human body has also evolved to be hardwired to these inevitable and “ideal” conditions, as it has done to day and night. The progress of civilization in the last several centuries has removed the limit of food, uncovered advancements in the medical field, invented technologies to use in place of human labor, and made it much easier to achieve our previous goal of surviving. What was previously inevitable is now evitable. Many people are fortunate enough to have the luxury to choose to live in an environment with “ideal” conditions. However, our bodies are still the ones that have evolved to withstand hardships and strain. The mismatch between this new environment lacking in hunger, germs, labor, and purpose and the body constructed for those conditions is the biggest challenge needed to be overcome for a healthy life.

First, let’s talk about health as it pertains to metabolism.

I have two scenarios to walk you through. In the first scenario, it is ten in the morning and you are hungry. What do you usually do in this situation? In the second scenario, it’s ten in the morning and a lion is hungry. What do you think the lion does in this situation? You probably answered that you would prepare something for yourself or go shopping, and that a lion would hunt for his meal.

Credit: http://www.wallpaperup.com/112543/lion_hunting_grass.html

Generally speaking, a lion goes hunting when it’s hungry. Hunger is a call to work in nature. Even for humans, eating three meals a day was not considered the norm until very recently in history. In fact, one or two meals a day was the common practice not so long ago. In my own early life, we used to eat only two meals a day. The first thing adults and children did in the morning was to go to work and school, respectively. The first meal was served from 9 – 10, after which we would return to our duties. The second meal wasn’t until the late afternoon. In winter, it was common to only eat one meal a day. I started eating three meals a day in my early teens. However, eating a meal first thing in the morning wasn’t part of my morning routine until after I graduated from college. Snacks entered my as a luxury while in my twenties. In my thirties, after moving to the US, food was more readily available to me than I had ever experienced before. Hunger could be satisfied at any moment with fast food, instant meals, or sugary drinks.

But even with such availability of food, my sense of hunger became uneasy and agitated. I felt compelled to eat more and more. The sooner I ate after beginning to feel the first pangs of hunger, the bigger my appetite became next time. I began to gain weight. I developed hypertension in my early forties. My blood pressure fluctuated as I wrestled with my condition for quite some time. In the process, the concept of fasting came to me with help from several books. I attempted a 72-hour fast but my strong stomach acid prevented me from finishing and I stopped at around the 40th hour. In the summer of 2016, I practiced eating two meals within a short period of time each. My weight loss was visible within a short period of time and my blood pressure could be maintained easily by exercising regularly. Another benefit is that my hunger has been tamed. The urge to eat has become less demanding. After four weeks of taking my meals within a window of 8 hours, I took a blood test at my yearly checkup. Compared with the results from a year ago, it was much improved: blood glucose was reduced; total lipids and LDL were lower; the HDL became higher (table below).

But most importantly, I felt better both mentally and physically. In fact, it’s likely that our bodies were built to function better under the duress of hunger. In my research, some publications indicated that fasting actually strengthens immunity and memory.

Traditionally, the two stages of satisfaction and hunger alternate with each other. Different metabolism applies in each of the two stages, which involve different parts of the metabolic system and likely hundreds of genes in different organs and tissues. Balance of the two stages will exercise the different components of metabolic system. Many people in this country are missing one half of this balance: hunger. This is likely the cause of many health problems today. The next time you feel hungry, try to remain hungry for a longer period of time. Condition yourself to find the proper balance between hunger and fullness.

Second, let’s talk about health as it pertains to the immune system.

Contact with germs, good or bad, is inevitable. This has been true for human beings since we began to exist. Our immune systems helps us survive in a world full of germs. The most common problem with the immune system is allergies, encompassing seasonal allergies as well as food allergies. This is definitely a problem here in US, which I’m sure many of us can attest to. I have been living in the U.S. for over 20 years and spent most of my time here without suffering from any allergies. People told me, “You’re safe if you don’t have it within the first 5 years.” And I was safe until my 18th spring here. My allergies began during a retreat one evening in the March of 2014. I started tearing up during a talk. When I went outside, more tears arose accompanied by sneezing and a tightness in my chest. I realized my tears were caused by the pollen from the surrounding trees. The most difficult symptom of my allergy was the congestion of my nose during the night. Many nights became sleepless ones. And even worse, my allergies grew from seasonal to yearlong. I looked into what might be the cause of the allergies. My surroundings had remained relatively unchanged, so it must have been something inside me that was different. My genes were not to blame. My food, mostly home cooked Chinese food, had changed very little. My weight had increased slowly for the first ten years here and had remained relatively stable ever since. The most drastic change I had made was concerning my oral hygiene. After ignoring advice from my dentist for many years, I finally started flossing daily in 2013. I was also using mouthwash and scraping my tongue. In January of 2014, I finally got an A+ at my dental checkup. No more advice was given. Beside these changes to my dental hygiene, the antibiotics I used in the winter of 2013-2014 to combat a lasting cough are likely another contributing factor. The combination of excessive oral hygiene and antibiotics had changed my oral microbiome in a profound way. Around that time, research about links between oral microbiome and allergies were gradually emerging.

Adapted from: Han, CS., A specific hygiene hypothesis. Med Hypotheses. 2016 Aug; 93:146-9

Beyond my personal story, there is an observed association between allergies and oral hygiene at a societal level. For example, this chart (right) shows an association between allergies and number of oral hygienist in the U.S. The number of oral hygienists in the US is used to indicate a level of public oral hygiene. Asthma is the representative of allergic diseases. This data was publicly available at the NIH and Department of Labor. The association of the two data sets is highly significant.

Without being restricted by any particular theory of operation or making any specific health claims, it is believed that oral microbiota interacts with the host largely through metabolites produced by its relevant bacterial members. Those metabolites, including but not limited to the short chain fatty acid, may influence the function of multiple biologic systems and organs, such as the immune system. Absence or severe reduction of the relevant bacteria may cause the immune system to malfunction, possibly by causing an oversensitivity to allergens.

It is believed that the immune system’s response to allergens may be regulated so that the associated allergic symptoms are suppressed relative to what an allergic reaction could gully amount to.  Evidence has further suggested that promoting healthy oral microbiota with certain substances may allow the immune system to function in a healthy manner with a healthy response to allergens.

Furthermore, due to the connectivity among the mouth, respiratory duct and lungs, healthy oral microbiota may lead to healthy microbiota in the lungs as well. Eventually the method may benefit the immune system which will in turn have a healthy response not only to allergic rhinitis but also relevant diseases affecting the lungs, such as asthma.

Beyond the respiratory tract, similar relationships between the immune system and microbes likely exist. For example, many bacteria in the gut produce short chain fatty acids and research has found less showers are associated with less skin allergies. Further examinations found that autoimmune diseases are close cousins of allergies rooted in related causes.

The lesson we have learned so far is that it is not necessary for one to go to extreme lengths to maintain personal hygiene. While researchers are trying to define the proper degree of hygiene practices, common sense can be applied in many situations. For example, one should shower less frequently upon observing dry or itchy skin after prolonged showers. Also, knowing the breeding grounds of “bad” germs is important.

Third, let’s talk about health as it pertains to circulation.

The inevitable related to circulation is labor. Hard labor was required in history not only to feed family members but also to defend one’s land. Such physical work not only strengthens muscles but also exercises the heart and lungs. The Industrial Revolution has relieved many people from hard labor. Thus, modern-day human beings are required to exercise (labor without any external purpose) if they want to remain healthy. Exercise is more beneficial when not used for weight loss but for a strong heart. Physical activity consumes limited amounts of energy in comparison to basic metabolism. For example, walking for an hour consumes only the amount of energy in a cookie or bagel (only 55 grams). Additionally, it’s easier to exercise when doing so for an ulterior purpose such as meeting friends, walking a dog, commuting to work, or even household chores. Exercise solely for health’s sake can become very boring. Health has no purpose above your happiness and fulfillment.

Forth, let’s talk about health as it pertains to mentality.

Mentality is obviously a complicated issue with much written on the topic. I would like to relay to you some segmented thought on the inevitabilities of purpose and faith and why they are important to mental health. The human brain was evolutionally selected to solve problems and answer questions. Purpose is the driver of the process. Nothing in history has been done without purpose. Historically, the main purpose for man has been to survive. According to Maslow’s hierarchy of needs, other purposes are secondary to survival and are related to different level of human needs, from physical to social to mental. The pursuit of self-actualization satisfies the highest need of the human soul.

The inevitability of faith stems from the enabling functions of the human brain. The following three brain functions are said to be the foundation of developing faith: the ability to infer the presence of organisms that might cause harm (agent detection), the ability to come up with causal narratives for natural events (etiology), and the ability to recognize that other people have minds of their own with their own beliefs, desires and intentions (theory of mind). These three adaptations (among others) allow human beings to imagine purposeful agents behind many observations that could not readily be explained otherwise, e.g. thunder, lightning, the movement of planets, complexity of life, etc. The emergence of a collective religious belief identifies the agents as deities. These explanations were later standardized and became widely accepted.

I want to emphasize that we should not conflict, confront or replace faith with science, or vice versa, because they are two separate scopes within the human perception of the world. Man knows the world through two processes, sense and imagination. In reality, the two are always applied together in order to perceive the physical world. Science mostly relies on the senses to prove a hypothesis derived from a limited imagination based on what is known. Religious belief is mostly imagination (faith) with the limited support of the senses. Historically, religion facilitated the development of imagination and led to the birth of scientific hypotheses. In a sense, it can be said that religion is the father of science.

Faith is the basis of a healthy and abundant life, the result of evolutionary selection. In ancient times, faith was a simple explanation for environmental phenomena. Among the uncontrollable, faith gave people something to grasp onto. Do we still need faith nowadays? If you do not think that science has enabled you to understand and to control everything, if you are not certain what your tomorrow will be like, faith can still provide an anchor. Just as Mark Twain put it in The Adventures of Tom Sawyer, “Earthly pleasure cannot satisfy the longings of the soul!” Material that is sensed can only satisfy the need of the sensing mind. The imagining mind can only be satisfied by human imagination. And the greatest of all human imagination is religious faith.

Finally, this summarizes the message I have discussed with you today.

In evolution, there is a phenomenon in which anything inevitable to life will eventually solidify into necessity. All four things – bacteria, hunger, labor, and faith are inevitable for human being. And human civilization during the last two centuries has made the previously inevitable evitable. Hunger, bacteria, and physical exertion have been part of our beings since the beginning and are likely still necessary and a key component of our bodily health. At the very least, they are not going to be eradicated in the near future. To lead a healthy life, we need to maintain these things properly. First of all, we should control the balance between hunger and satisfaction. Historically, humans have lived under conditions of periodically uncontrolled hunger due to the limited availability of food. Instant satisfaction or the complete removal of hunger halts the molecular machine for metabolism in hunger and may cause it to malfunction. Second of all, we need to make peace with bacteria in and around us. A major issue concerning the health of the immune system is that essential bacteria become vulnerable due to excessive hygiene practices. These bacteria can be removed or reduced significantly, especially while we fight infectious diseases. The absence or reduction of the essential bacteria can cause a malfunction of the immune system. We discussed oral bacteria as an example, but there are also beneficial bacteria on our skin and in our digestive systems as well as in the environment around us. Your immune system can only function properly under the proper influence of bacterial interactions. Otherwise, problems will develop, not only in the form of allergies, but also in the form of autoimmune diseases. Third of all, remember to exercise properly. Fourthly and finally, finding a purpose or a faith is a necessity in the pursuit of self-fulfillment and mental health. This has become even more important in modern society because the goal of survival has become much easier.

If anything, take these messages with you: starvation can kill you but fasting will make you healthier. Pathogens can sicken you but most bacteria make you more formidable. Hard labor can cause injury but frequent physical work makes you stronger. Superstition can make you a fool but faith will give you hope. So remember these four things: fasting, bacteria, exercise, and faith. Then apply them according to your own needs and balance them with their “ideal” conditions, fullness, clean, rest, and freedom. They will elevate you to a healthier and happier life, and one rich with mental, physical, and emotional accomplishments.

Further reading:

  • Obesity Code
    ― by Jason Fung
  • Good Germs, Bad Germs
    ― by Jessica Snider Sachs
  • Good Gut
    ―by Justin Sonnenburg and Erica Sonnenburg
  • Periodical Fasting
    ― by Christian Vlad Zot